SSBH 2025

Day 2 May 30(Fri) 09:00-10:00	Oral Presentation 1 Room 1

Chair(s): Sang Wan Kim (Seoul National University, Korea), Jung-Ho Shin (Korea University, Korea)

09:00-09:10	Evaluation of the Efficacy of ZOledronic Acid Administered Once or Twice After Different Durations of DenosuMab Treatment in Postmenopausal Women with Osteoporosis (ZOOM): A Prospective, Single-Center, Open-Label, Phase IV Study Sung Joon Cho (Yonsei University College of Medicine, Korea)
09:10-09:20	Impact of Digital Rehabilitation Modalities: AI-Driven Rehabilitation Versus Augmented Reality Rehabilitation on Bone Mineral Density, Physical And Muscle-Bone Biomarkers in Older Adults with Osteosarcopenia - A Randomized Control Trial. Gopal Nambi (Prince Sattam bin Abdulaziz University, Saudi Arabia)
09:20-09:30	Longitudinal Deterioration in Nutritional Status and Its Association with Increased Risk of Sarcopenia in Community-Dwelling Aged Adults Ho Jun Lim (Seoul National University Bundang Hospital, Korea)
09:30-09:40	The Potential Role of Calcitriol in Maintaining Calcium Levels in Osteoporosis Patients Receiving Denosumab Sung Joon Cho (Yonsei University College of Medicine, Korea)
09:40-09:50	Impact of Smoking, Diabetes, and Exercise on Dementia Risk in Women with Osteoporosis : A Nationwide Cohort Study Hee Jung Son (Eulji University School of Medicine, Korea)
09:50-10:00	Comparison of Radiological and Functional Outcomes of Conservative Treatment with Teriparatide and Denosumab in Thoracolumbar Osteoporotic Vertebral Fracture Ikchan Jeon (Yeungnam University Hospital, Korea)

Day 2 May 30(Fri) 09:00-10:00	Oral Presentation 2 Room 2

Chair(s): Hyun-Ju Kim (Kyungpook National University, Korea), Je-Hwang Ryu (Chonnam National University, Korea)

09:00-09:10	Research on Human-Derived Autologous Bone Culture Medium for Promoting Bone Fusion in Spinal Surgery Subum Lee (Korea University Anam Hospital, College of Medicine, Korea)
09:10-09:20	Osteocyte-Mediating Inter-Organ Crosstalk upon Exercise Sion Lee (Korea Advanced Institute of Science and Technology, Korea)
09:20-09:30	Palm Tocotrienol Enhanced Calcium Phosphate Cement for Bone Regeneration in Ovariectomised Rats Wong Sok Kuan (Universiti Kebangsaan Malaysia, Malaysia)
09:30-09:40	Glutamine Metabolism Through the GS-HBP-OGT-GLS Network Regulates Post-Traumatic Heterotopic Ossification Kang Heeseog (University of Texas Southwestern, United States)
09:40-09:50	Synthetic Organochlorines Exert Bone Anabolic Activity by Modulating CCN3 Signaling in Osteoblasts Zhang Qian (China Agricultural University, China)

Day 2 May 30(Fri) 09:00-09:50	Meet the Expert 1 Room 3

09:00-09:50	Navigating a Career in Academic Biomedical Research Thomas L. Clemens (University of Maryland, USA)

Day 2 May 30(Fri) 10:05-10:55	Plenary Lecture 1 Room 1

Chair(s): Chan Soo Shin (Seoul National University, Korea)

10:05-10:55	Cancer-Associated Muscle Dysfunction: What’s Bone Got to Do With It? Theresa A. Guise (The University of Texas MD Anderson Cancer Center, USA)

Day 2 May 30(Fri) 11:10-12:25	Symposium 1. Antiresorptives: What We’ve Learned and What Lies Ahead Room 1

Antiresorptive therapies have played a pivotal role in osteoporosis management, continuously proving their clinical efficacy and value. This symposium will reflect on past clinical experiences and explore strategies for current and future treatment approaches. The first lecture, Denosumab Beyond 10 Years: Balancing Long-Term Benefits and Risks, will be delivered by world-renowned expert Professor Michael R. McClung. He will provide an in-depth discussion on the balance between the long-term benefits and potential risks of denosumab use beyond a decade. In the second lecture, Timing Matters in Denosumab: Planning Ahead to Prevent Rebound Fractures, Professor Koung Min Kim will present optimal strategies to prevent rebound fractures during the discontinuation of denosumab therapy. The final lecture, Beyond Bone Health: Exploring the Mortality Impact of Antiresorptive Therapy, will be presented by Professor Kyoung Jin Kim, highlighting the effects of antiresorptive therapies on reducing mortality beyond their benefits to bone health. This session offers a valuable opportunity to gain the latest insights into antiresorptive therapies, which remain central to osteoporosis treatment, and to translate these insights into clinical practice.

Chair(s): Dong Won Byun (Soonchunhyang University, Korea), Seongbin Hong (Inha University, Korea)

11:10-11:35	Denosumab Beyond 10 Years: Balancing Long-Term Benefits and Risks Michael R McClung (Oregon Osteoporosis Center, USA)
11:35-12:00	Timing Matters in Denosumab: Planning Ahead to Prevent Rebound Fractures Kyoung Min Kim (Yonsei University, Korea)
12:00-12:25	Beyond Bone Health: Exploring the Mortality Impact of Antiresorptive Therapy Kyoung Jin Kim (Korea University, Korea)

Day 2 May 30(Fri) 11:10-12:25	Symposium 2. Advances in Bone Research: Signaling Pathways of Osteoblasts Room 2

The regulation of osteoblast function and bone formation is a fundamental aspect of bone metabolism research. A deeper understanding of osteoblast signaling pathways is crucial for developing effective bone regeneration strategies and therapeutic interventions. This symposium will present the latest discoveries in osteoblast signaling mechanisms and their potential clinical applications. Professor Chao Liu (Southern University of Science and Technology, China) has been investigating the role of mechanical stimuli in bone regeneration. His presentation will focus on how mechanical signals regulate the interaction between blood vessels and bone tissue, shedding light on their impact on bone repair and regeneration. Professor Ji Hyun Park (Department of Endocrinology and Metabolism, Jeonbuk National University Medical School, Korea) recently identified a novel mechanism by which parathyroid hormone (PTH 1-34) enhances bone formation through the PAK4-β-catenin signaling pathway. Her talk will explore the implications of this discovery for PTH-based osteoporosis treatment and its clinical significance. Professor Eui Kyun Park (School of Dentistry, Kyungpook National University, Korea) has recently elucidated the role of DOCK5 in regulating the BMP2 signaling pathway in osteoblasts. His presentation will discuss the regulatory mechanisms of BMP2 signaling in bone regeneration and its therapeutic potential in clinical applications. This session aims to share cutting-edge research on osteoblast signaling pathways and explore novel therapeutic strategies for bone diseases. We invite researchers and clinicians to join us for this insightful discussion on the future of bone health research.

Chair(s): Soo Young Lee (Ewha Womans University, Korea), Nacksung Kim (Chonnam National University, Korea)

11:10-11:35	Mechanical Regulation of Angiogenesis-Osteogenesis Coupling during Bone Regeneration Chao Liu (Southern University of Science and Technology, China)
11:35-12:00	A Novel PTH(1-34) Signaling Pathway in Osteoblasts Ji Hyun Park (Jeonbuk National University, Korea)
12:00-12:25	Regulation of BMP2 Signaling for Bone Regeneration and Clinical Research Eui Kyun Park (Kyungpook National University, Korea)

Day 2 May 30(Fri) 11:10-12:25	Working Group 1. Fracture Liaison Service Working Group K FLS in Korea: Everything You Need to Know Room 3

Chair(s): Jae-Young Lim (Seoul National University, Korea)

11:10-11:35	Legal and Policy Consideration of FLS with Coordinators in Korea Seung Hoon Kim (Soonchunhyang University, Korea)
11:35-12:00	Introduction and Clinical Results of Daejeon Eulji FLS Yonghan Cha (Eulji University, Korea)
12:00-12:25	Economic Impact Evaluation of Coordinator Services to Prevent Re-Fractures in Patients with Femur Fractures Jae-Hyun Kim (Dankook University, Korea)

Day 2 May 30(Fri) 12:25-12:40	Luncheon Symposium 1 Room 1

Chair(s): Ki-Hyun Baek (The Catholic University of Korea, Korea)

12:25-12:40	Optimal Sequencing in Osteoporosis Care Michael R McClung (Oregon Osteoporosis Center, USA)

Day 2 May 30(Fri) 12:25-12:40	Luncheon Symposium 2 Room 2

Chair(s): Hyun Sik Gong (Seoul National University, Korea)

12:25-12:40	The New Era of Osteoporosis Treatment with Denosumab (STOBOCLO®) Yunkyung Jeon (Pusan National University, Korea)

Day 2 May 30(Fri) 12:40-12:55	Luncheon Symposium 3 Room 1

Chair(s): Ki-Hyun Baek (The Catholic University of Korea, Korea)

12:40-12:55	Efficacy of Different Anti-Resorptive Therapies Following Denosumab Discontinuation: A Multicenter Real-World Study in Korea (MAXCARE Study) Hyo-Jeong Kim (Eulji University, Korea)

Day 2 May 30(Fri) 13:25-14:40	Symposium 3. Keynote Symposium AI in Action: Transforming Translational and Clinical Paradigms Room 1

AI technology is revolutionizing traditional medical paradigms, transforming translational and clinical research at its core. This symposium explores the practical applications of AI in areas such as drug discovery, fracture risk assessment, and musculoskeletal health improvement. The first lecture, presented by Professor Jaewoo Kang from Korea University, will delve into how AI is reshaping drug discovery in the era of large language models. This session will highlight the latest trends and challenges in leveraging AI to discover and develop new drugs. The second lecture, by Professor Sung Hye Kong from Seoul National University, will explore the role of AI in fracture risk assessment. The talk will focus on advancements in AI technology and its practical applications in managing fracture risk. The final lecture, by Professor Jun-Il Yoo from Inha University, will discuss how AI can be utilized to improve muscle health. The presentation will examine how AI can aid in assessing muscle function and conditions, supporting better treatment and management strategies. Through this symposium, we aim to highlight how AI is driving innovation in translational research and clinical practice, reshaping the future of medicine.

Chair(s): Yumie Rhee (Yonsei University, Korea), Young-Kyun Lee (Seoul National University, Korea)

13:25-13:50	AI-Driven Drug Discovery in the Large Language Model Era Jaewoo Kang (Korea University, Korea)
13:50-14:15	Incorporating AI in Assessing Fracture Risk: Predicting the Unpredictable Sung Hye Kong (Seoul National University, Korea)
14:15-14:40	Developing AI-Driven Digital Biomarkers for Sarcopenia Detection Jun-Il Yoo (Inha University, Korea)

Day 2 May 30(Fri) 13:25-14:40	Working Group 2. PTH Working Group Deep Dive into PTH World Room 3

The mutation in the PTH gene identified in a family with familial hypocalcemia not only provides a molecular genetic basis for understanding the pathogenesis of the disease, but also presents a highly promising potential for the development of clinically useful therapeutic agents targeting related diseases. This symposium has been organized to offer an opportunity for in-depth discussion of the research conducted thus far on ^R25CPTH.

Chair(s): Je-Yong Choi (Kyungpook National University, Korea)

13:25-13:40	Almost Everything about Dimeric ^R25CPTH(1-34) in 10 Minutes Sihoon Lee (Gachon University, Korea)
13:40-14:10	Enhancing Bone Regeneration and Osseointegration Using rhPTH(1-34) and Dimeric ^R25CPTH(1-34) in an Osteoporotic Beagle Model Jin-Woo Kim (Ewha Womans University, Korea)
14:10-14:40	Dimeric ^R25CPTH(1-34) Activates the Parathyroid Hormone-1 Receptor in Vitro and Stimulates Bone Formation in Osteoporotic Female Mice Xiangguo Che (Kyungpook National University, Korea)

Day 2 May 30(Fri) 14:40-15:30	Plenary Lecture 2 Room 1

We are honored to host Professor William D. Leslie as a plenary speaker for the SSBH clinical session. Renowned globally for his contributions to osteoporosis and fracture risk assessment, Professor Leslie has played a pivotal role in advancing the clinical application and development of tools. His groundbreaking research has significantly influenced both academic progress and practical patient care in this field. In this lecture, Professor Leslie will discuss the latest advancements in fracture risk assessment, focusing on clinical applications and future directions. Specifically, he will address the strengths and limitations of current fracture risk assessment tools, highlight the implications of emerging data and technologies, and explore the transformative potential of precision medicine and digital health in osteoporosis management. Additionally, during the Meet the Expert session, attendees will have the opportunity to gain practical insights into managing fracture risk and developing treatment plans, guided by Professor Leslie’s extensive expertise. We warmly invite KSBMR members to join this invaluable session to engage with a world-leading expert in the field of bone health and osteoporosis research.

Chair(s): Ho-Yeon Chung (Kyung Hee University, Korea)

14:40-15:30	Advances in Fracture Risk Assessment: Clinical Applications and Future Directions William D. Leslie (University of Manitoba, Canada)

Day 2 May 30(Fri) 15:45-17:00	KSBMR-ASBMR-JSBMR Joint Symposium Room 1

This symposium is a special event co-hosted by KSBMR, ASBMR, and JSBMR, bringing together leading researchers from around the world to share the latest research trends in bone metabolism and related diseases. In this session, three distinguished speakers will present in-depth talks on their respective research topics. First, Professor Se Hwan Mun (Sookmyung Women’s University, Korea) will present his research on the role of TACE (Adam17) in inflammation-mediated bone loss, offering important insights into bone metabolism from an immunological perspective. Next, Professor Kyung Hyun Park-Min (Weill Cornell Medical College, USA), the ASBMR representative speaker, will discuss the classification of osteoclast-specific markers and their impact on bone metabolism. This presentation will provide a deep exploration of the genes playing a critical role in osteoclast differentiation. Finally, Professor Yuki Matsushita (Nagasaki University, Japan), representing JSBMR, will discuss the dual roles of skeletal stem cells in regeneration and exhaustion. His presentation will offer a new perspective on the latest trends in skeletal stem cell research and their crucial role in bone metabolism. This session will be a valuable opportunity to gain a multi-dimensional and in-depth understanding of bone metabolism, immunology, and bone regeneration, as well as explore future research directions through the presentations of leading experts from around the world.

Chair(s): Hiroshi Takayanagi (The University of Tokyo, Japan), Ki-Hyun Baek (The Catholic University of Korea, Korea)

15:45-16:10	Immunoporosis: The Regulatory Role of TACE (ADAM17) in Inflammation-Mediated Bone Loss Se Hwan Mun (Sookmyung Women's University, Korea)
16:10-16:35	Osteoclast Specific Signatures Kyung Hyun Park-Min (Weill Cornell Medical College, USA)
16:35-17:00	Skeletal Stem Cell Landscape: The Dual Fates of Regeneration and Exhaustion Yuki Matsushita (Nagasaki University, Japan)

Day 2 May 30(Fri) 15:45-16:35	Meet the Expert 2 Room 3

15:45-16:35	Bisphosphonate Holidays: When and How? Michael R McClung (Oregon Osteoporosis Center, USA)

Scientific Program