Osteoimmunology is a field that studies the complex interactions between the skeletal and immune systems, playing a crucial role in understanding the pathogenesis of various bone and immune-related diseases. The signaling processes between immune cells and bone cells regulate bone formation and resorption, with inflammatory cytokines and immune regulatory factors playing essential roles in these processes. Recent studies indicate that changes in the immune system are closely linked to the progression of diseases such as osteoporosis, rheumatoid arthritis, and osteoarthritis, leading to the development of novel therapeutic strategies. In particular, active research is being conducted on the regulatory mechanisms of macrophages and osteoclasts, the relationship between circadian rhythms and bone metabolism, and the impact of inflammatory responses on bone loss.
This KSBMR-KCR Joint Symposium will introduce the latest research in the field of osteoimmunology, focusing on the mechanisms by which macrophage-derived osteoclasts regulate the balance between bone resorption and formation and their role in inflammatory arthritis. Additionally, the symposium will comprehensively examine the importance of maintaining osteoimmune homeostasis based on the interaction between immune responses and bone metabolism. Furthermore, it will analyze the effects of immune cells and circadian rhythm changes on cartilage and bone tissue, proposing therapeutic strategies for bone diseases. These studies provide critical foundational knowledge for developing immune regulation-based treatments for refractory bone diseases, demonstrating the essential role of osteoimmune approaches in the future treatment of bone metabolic diseases. Moreover, by integrating research in bone metabolism and immunology, this symposium aims to deepen the understanding of the pathological mechanisms of bone diseases and propose new directions for osteoimmune-based therapeutic development.