SSBH 2025

Day 2 May 30(Fri) 09:00-10:00	Oral Presentation 1 Room 1

Chair(s): Sang Wan Kim (Seoul National University, Korea), Jung-Ho Shin (Korea University, Korea)

Day 2 May 30(Fri) 10:05-10:55	Plenary Lecture 1 Room 1

Chair(s): Chan Soo Shin (Seoul National University, Korea)

10:05-10:55	Cancer-Associated Muscle Dysfunction: What’s Bone Got to Do With It? Theresa A. Guise (The University of Texas MD Anderson Cancer Center, USA)

Day 2 May 30(Fri) 11:10-12:25	Symposium 1. Antiresorptives: What We’ve Learned and What Lies Ahead Room 1

Antiresorptive therapies have played a pivotal role in osteoporosis management, continuously proving their clinical efficacy and value. This symposium will reflect on past clinical experiences and explore strategies for current and future treatment approaches. The first lecture, Denosumab Beyond 10 Years: Balancing Long-Term Benefits and Risks, will be delivered by world-renowned expert Professor Michael R. McClung. He will provide an in-depth discussion on the balance between the long-term benefits and potential risks of denosumab use beyond a decade. In the second lecture, Timing Matters in Denosumab: Planning Ahead to Prevent Rebound Fractures, Professor Koung Min Kim will present optimal strategies to prevent rebound fractures during the discontinuation of denosumab therapy. The final lecture, Beyond Bone Health: Exploring the Mortality Impact of Antiresorptive Therapy, will be presented by Professor Kyoung Jin Kim, highlighting the effects of antiresorptive therapies on reducing mortality beyond their benefits to bone health. This session offers a valuable opportunity to gain the latest insights into antiresorptive therapies, which remain central to osteoporosis treatment, and to translate these insights into clinical practice.

Chair(s): Dong Won Byun (Soonchunhyang University, Korea), Seongbin Hong (Inha University, Korea)

11:10-11:35	Denosumab Beyond 10 Years: Balancing Long-Term Benefits and Risks Michael R McClung (Oregon Osteoporosis Center, USA)
11:35-12:00	Timing Matters in Denosumab: Planning Ahead to Prevent Rebound Fractures Kyoung Min Kim (Yonsei University, Korea)
12:00-12:25	Beyond Bone Health: Exploring the Mortality Impact of Antiresorptive Therapy Kyoung Jin Kim (Korea University, Korea)

Day 2 May 30(Fri) 12:25-12:40	Luncheon Symposium 1 Room 1

Chair(s): Ki-Hyun Baek (The Catholic University of Korea, Korea)

12:25-12:40	Optimal Sequencing in Osteoporosis Care Michael R McClung (Oregon Osteoporosis Center, USA)

Day 2 May 30(Fri) 13:25-14:40	Symposium 3. Keynote Symposium AI in Action: Transforming Translational and Clinical Paradigms Room 1

AI technology is revolutionizing traditional medical paradigms, transforming translational and clinical research at its core. This symposium explores the practical applications of AI in areas such as drug discovery, fracture risk assessment, and musculoskeletal health improvement. The first lecture, presented by Professor Jaewoo Kang from Korea University, will delve into how AI is reshaping drug discovery in the era of large language models. This session will highlight the latest trends and challenges in leveraging AI to discover and develop new drugs. The second lecture, by Professor Sung Hye Kong from Seoul National University, will explore the role of AI in fracture risk assessment. The talk will focus on advancements in AI technology and its practical applications in managing fracture risk. The final lecture, by Professor Jun-Il Yoo from Inha University, will discuss how AI can be utilized to improve muscle health. The presentation will examine how AI can aid in assessing muscle function and conditions, supporting better treatment and management strategies. Through this symposium, we aim to highlight how AI is driving innovation in translational research and clinical practice, reshaping the future of medicine.

Chair(s): Yumie Rhee (Yonsei University, Korea), Young-Kyun Lee (Seoul National University, Korea)

13:25-13:50	AI-Driven Drug Discovery in the Large Language Model Era Jaewoo Kang (Korea University, Korea)
13:50-14:15	Incorporating AI in Assessing Fracture Risk: Predicting the Unpredictable Sung Hye Kong (Seoul National University, Korea)
14:15-14:40	Developing AI-Driven Digital Biomarkers for Sarcopenia Detection Jun-Il Yoo (Inha University, Korea)

Day 2 May 30(Fri) 14:40-15:30	Plenary Lecture 2 Room 1

We are honored to host Professor William D. Leslie as a plenary speaker for the SSBH clinical session. Renowned globally for his contributions to osteoporosis and fracture risk assessment, Professor Leslie has played a pivotal role in advancing the clinical application and development of tools. His groundbreaking research has significantly influenced both academic progress and practical patient care in this field. In this lecture, Professor Leslie will discuss the latest advancements in fracture risk assessment, focusing on clinical applications and future directions. Specifically, he will address the strengths and limitations of current fracture risk assessment tools, highlight the implications of emerging data and technologies, and explore the transformative potential of precision medicine and digital health in osteoporosis management. Additionally, during the Meet the Expert session, attendees will have the opportunity to gain practical insights into managing fracture risk and developing treatment plans, guided by Professor Leslie’s extensive expertise. We warmly invite KSBMR members to join this invaluable session to engage with a world-leading expert in the field of bone health and osteoporosis research.

Chair(s): Ho-Yeon Chung (Kyung Hee University, Korea)

14:40-15:30	Advances in Fracture Risk Assessment: Clinical Applications and Future Directions William D. Leslie (University of Manitoba, Canada)

Day 2 May 30(Fri) 15:45-17:00	KSBMR-ASBMR-JSBMR Joint Symposium Room 1

This symposium is a special event co-hosted by KSBMR, ASBMR, and JSBMR, bringing together leading researchers from around the world to share the latest research trends in bone metabolism and related diseases. In this session, three distinguished speakers will present in-depth talks on their respective research topics. First, Professor Se Hwan Mun (Sookmyung Women’s University, Korea) will present his research on the role of TACE (Adam17) in inflammation-mediated bone loss, offering important insights into bone metabolism from an immunological perspective. Next, Professor Kyung Hyun Park-Min (Weill Cornell Medical College, USA), the ASBMR representative speaker, will discuss the classification of osteoclast-specific markers and their impact on bone metabolism. This presentation will provide a deep exploration of the genes playing a critical role in osteoclast differentiation. Finally, Professor Yuki Matsushita (Nagasaki University, Japan), representing JSBMR, will discuss the dual roles of skeletal stem cells in regeneration and exhaustion. His presentation will offer a new perspective on the latest trends in skeletal stem cell research and their crucial role in bone metabolism. This session will be a valuable opportunity to gain a multi-dimensional and in-depth understanding of bone metabolism, immunology, and bone regeneration, as well as explore future research directions through the presentations of leading experts from around the world.

Chair(s): Hiroshi Takayanagi (The University of Tokyo, Japan), Ki-Hyun Baek (The Catholic University of Korea, Korea)

15:45-16:10	Immunoporosis: The Regulatory Role of TACE (ADAM17) in Inflammation-Mediated Bone Loss Se Hwan Mun (Sookmyung Women's University, Korea)
16:10-16:35	Osteoclast Specific Signatures Kyung Hyun Park-Min (Weill Cornell Medical College, USA)
16:35-17:00	Skeletal Stem Cell Landscape: The Dual Fates of Regeneration and Exhaustion Yuki Matsushita (Nagasaki University, Japan)

Scientific Program