The regulation of osteoblast function and bone formation is a fundamental aspect of bone metabolism research. A deeper understanding of osteoblast signaling pathways is crucial for developing effective bone regeneration strategies and therapeutic interventions. This symposium will present the latest discoveries in osteoblast signaling mechanisms and their potential clinical applications. Professor Chao Liu (Southern University of Science and Technology, China) has been investigating the role of mechanical stimuli in bone regeneration. His presentation will focus on how mechanical signals regulate the interaction between blood vessels and bone tissue, shedding light on their impact on bone repair and regeneration. Professor Ji Hyun Park (Department of Endocrinology and Metabolism, Jeonbuk National University Medical School, Korea) recently identified a novel mechanism by which parathyroid hormone (PTH 1-34) enhances bone formation through the PAK4-β-catenin signaling pathway. Her talk will explore the implications of this discovery for PTH-based osteoporosis treatment and its clinical significance. Professor Eui Kyun Park (School of Dentistry, Kyungpook National University, Korea) has recently elucidated the role of DOCK5 in regulating the BMP2 signaling pathway in osteoblasts. His presentation will discuss the regulatory mechanisms of BMP2 signaling in bone regeneration and its therapeutic potential in clinical applications. This session aims to share cutting-edge research on osteoblast signaling pathways and explore novel therapeutic strategies for bone diseases. We invite researchers and clinicians to join us for this insightful discussion on the future of bone health research.